研究業績

2025年

原著論文

• "Deterioration in ankle reflex is associated with a reduced estimated glomerular filtration rate in patients with type 2 diabetes: A retrospective observational cohort study"
  T. Muramatsu, D. Yamamuro, A. Kushiyama and T. Kikuchi
  J Diabetes Investig 16, 2, 225-235 (2025).

  • URL
  • DOI: 10.1111/jdi.14348

  39531008
• "Analysis of sleep medication-induced parasomnias using the Japanese Adverse Drug Event Report database"
  S. Kobayashi, K. Shinozaki, H. Nagano, A. Miyamori, T. Muramatsu and A. Kushiyama
  J Sleep Res, e70009 (2025).

  • URL
  • DOI: 10.1111/jsr.70009

  39972525

2024年

原著論文

• "Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action"
  T. Yamamotoya, Y. Ohata, Y. Akasaka, S. Hasei, M. K. Inoue, Y. Nakatsu, M. Kanna, H. Yamazaki, A. Kushiyama, M. Fujishiro, H. Ono, H. Sakoda, T. Yamada, H. Ishihara and T. Asano
  PNAS Nexus 3, 4, pgae150 (2024).

  • URL
  • DOI: 10.1093/pnasnexus/pgae150

  38681675
• "Effect of the Xanthine Oxidase Inhibitor, Febuxostat, on WBC Count in Asymptomatic Hyperuricemia: Subanalysis of the Randomized PRIZE Study"
  M. Takeshita, A. Tanaka, H. Yoshida, I. Nakamura, Y. Shibata, S. Hata, A. Kushiyama, M. Okutsu, T. Ishizu and K. Node
  J Atheroscler Thromb 31, 6, 864-875 (2024).

  • URL
  • DOI: 10.5551/jat.64574

  38220209
• "Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice"
  R. Sugiyama, J. Hanaguri, H. Yokota, A. Kushiyama, S. Kushiyama, T. Kikuchi, T. Igarashi, M. Iketani, I. Ohsawa, S. Harino, H. Nakashizuka, S. Yamagami and T. Nagaoka
  Transl Vis Sci Technol 13, 10, 36 (2024).

  • URL
  • DOI: 10.1167/tvst.13.10.36

  39446362
• "Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema"
  Y. Saima, H. Yokota, A. Kushiyama, J. Hanaguri, A. Ohno, K. Takase, R. Sugiyama, K. Muranaka, S. Yamagami and T. Nagaoka
  Sci Rep 14, 1, 13798 (2024).

  • URL
  • DOI: 10.1038/s41598-024-63435-8

  38877041
• "Impairment of flicker-induced increase in retinal blood flow in diabetic pigs"
  T. Nagaoka, H. Yokota, M. Watanabe, H. Aso, K. Takase, J. Hanaguri, A. Ohno, A. Kushiyama, S. Harino and S. Yamagami
  Jpn J Ophthalmol 68, 4, 362-366 (2024).

  • URL
  • DOI: 10.1007/s10384-024-01073-3

  38874665

症例報告

• "Vortioxetine Exposure During Pregnancy and Lactation: A Japanese Case Study of Neonatal Implications and Quantitative Milk and Plasma Analyses"
  M. Kiribayashi, T. Suda, M. Takahashi, M. Ishikawa, R. Watanabe, K. Ishioka, S. Nakamura and A. Kushiyama
  Breastfeed Med 19, 8, 659-662 (2024).

  • URL
  • DOI: 10.1089/bfm.2024.0005

  38726594

2023年

原著論文

• "Dilation of porcine retinal arterioles to nobiletin, a polymethoxyflavonoid: Roles of nitric oxide and voltage-dependent potassium channel"
  M. Watanabe, Y. Miyata, A. Ohno, H. Yokota, K. Takase, J. Hanaguri, A. Kushiyama, S. Yamagami, S. Harino and T. Nagaoka
  Exp Eye Res 233, 109548 (2023).

  • URL
  • DOI: 10.1016/j.exer.2023.109548

  37348671
• "A pilot study of diabetic retinopathy in a porcine model of maturity onset diabetes of the young type 3 (MODY3)"
  K. Takase, H. Yokota, A. Ohno, M. Watanabe, A. Kushiyama, S. Kushiyama, S. Yamagami and T. Nagaoka
  Exp Eye Res 227, 109379 (2023).

  • URL
  • DOI: 10.1016/j.exer.2022.109379

  36608813
• "Identification of Prescribing Patterns in Hemodialysis Outpatients Taking Multiple Medications"
  H. Nagano, K. Tomori, M. Koiwa, S. Kobayashi, M. Takahashi, H. Makabe, H. Okada and A. Kushiyama
  Pharmacy (Basel) 11, 2 (2023).

  • URL
  • DOI: 10.3390/pharmacy11020043

  36961021
• "Renally inappropriate medications in elderly outpatients and inpatients with an impaired renal function"
  S. Kobayashi, N. Sugama, H. Nagano, M. Takahashi and A. Kushiyama
  Hosp Pract (1995) 51, 2, 76-81 (2023).

  • URL
  • DOI: 10.1080/21548331.2023.2173412

  36695817
• "Analysis of Adverse Events of Cholinesterase Inhibitors and NMDA Receptor Antagonists on Arrhythmias Using the Japanese Adverse Drug Event Report Database"
  S. Kobayashi, N. Sugama, H. Nagano, A. Miyamori, M. Takahashi and A. Kushiyama
  Drugs Real World Outcomes 10, 2, 321-329 (2023).

  • URL
  • DOI: 10.1007/s40801-023-00362-6

  37086360
• "Comparison of Weight Reduction, Change in Parameters and Safety of a Very Low Carbohydrate Diet in Comparison to a Low Carbohydrate Diet in Obese Japanese Subjects with Metabolic Disorders"
  T. Kikuchi, A. Kushiyama, M. Yanai, C. Kashiwado, T. Seto and M. Kasuga
  Nutrients 15, 6 (2023).

  • URL
  • DOI: 10.3390/nu15061342

  36986072
• "Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines"
  M. Kanna, Y. Nakatsu, T. Yamamotoya, A. Kushiyama, M. Fujishiro, H. Sakoda, H. Ono, K. Arihiro and T. Asano
  Int J Mol Sci 24, 10 (2023).

  • URL
  • DOI: 10.3390/ijms24108847

  37240193
• "Development of a simple high-performance liquid chromatography-ultraviolet method for sotorasib quantification in human plasma: Implications for therapeutic drug monitoring"
  E. Hikita, Y. Gando, H. Chubachi, M. Shirota, A. Kushiyama and T. Yasu
  Drug Discov Ther 17, 4, 289-293 (2023).

  • URL
  • DOI: 10.5582/ddt.2023.01043

  37599084
• "Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells"
  Y. Akasaka, S. Hasei, Y. Ohata, M. Kanna, Y. Nakatsu, H. Sakoda, M. Fujishiro, A. Kushiyama, H. Ono, A. Matsubara, N. Hinata, T. Asano and T. Yamamotoya
  Int J Mol Sci 24, 21 (2023).

  • URL
  • DOI: 10.3390/ijms242116011

  37958994

2022年

原著論文

• "Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases"
  T. Yamamotoya, S. Hasei, Y. Akasaka, Y. Ohata, Y. Nakatsu, M. Kanna, M. Fujishiro, H. Sakoda, H. Ono, A. Kushiyama, H. Misawa and T. Asano
  Sci Rep 12, 1, 1966 (2022).

  • URL
  • DOI: 10.1038/s41598-022-05884-7

  35121777
• "Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study"
  T. Takao, H. Yanagisawa, M. Suka, Y. Yoshida, Y. Onishi, T. Tahara, T. Kikuchi, A. Kushiyama, M. Anai, K. Takahashi, S. Wakabayashi Sugawa, H. Yamazaki, S. Kawazu, Y. Iwamoto, M. Noda and M. Kasuga
  J Diabetes Investig 13, 2, 299-307 (2022).

  • URL
  • DOI: 10.1111/jdi.13659

  34533892
• "Decline in renal function associated with cardiovascular autonomic neuropathy positively coordinated with proteinuria in patients with type 2 diabetes"
  T. Muramatsu, M. Takahashi, R. Kakinuma, T. Sato, M. Yamamoto, M. Akazawa, K. Tanaka, T. Kikuchi and A. Kushiyama
  J Diabetes Investig 13, 1, 102-111 (2022).

  • URL
  • DOI: 10.1111/jdi.13625

  34228899
• "Synergistic deterioration of prognosis associated with decreased grip strength and hyporesponse to erythropoiesis-stimulating agents in patients undergoing hemodialysis"
  S. Kobayashi, K. Tanaka, J. Hoshino, S. Hara, A. Kushiyama, Y. Tanaka, S. Motonishi, K. Sakai and T. Ozawa
  Ren Fail 44, 1, 1801-1810 (2022).

  • URL
  • DOI: 10.1080/0886022X.2022.2106873

  36305202
• "The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice"
  J. Hanaguri, H. Yokota, A. Kushiyama, S. Kushiyama, M. Watanabe, S. Yamagami and T. Nagaoka
  Int J Mol Sci 23, 3 (2022).

  • URL
  • DOI: 10.3390/ijms23031362

  35163285
• "Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice"
  J. Hanaguri, N. Nagai, H. Yokota, A. Kushiyama, M. Watanabe, S. Yamagami and T. Nagaoka
  Pharmaceutics 14, 2 (2022).

  • URL
  • DOI: 10.3390/pharmaceutics14020384

  35214116
• "Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes"
  H. Yokota, H. Hayashi, J. Hanaguri, S. Yamagami, A. Kushiyama, H. Nakagami and T. Nagaoka
  PLoS One 17, 1, e0262568 (2022).

  • URL
  • DOI: 10.1371/journal.pone.0262568

  35041699
• "Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice"
  J. Hanaguri, H. Yokota, A. Kushiyama, S. Kushiyama, M. Watanabe, S. Yamagami and T. Nagaoka
  Front Physiol 13, 788034 (2022).

  • URL
  • DOI: 10.3389/fphys.2022.788034

  35283788

総説

• "[Metabolism-dependent Vascular Pathophysiology in Adult Diseases]"
  A. Kushiyama, M. Takahashi, S. Kushiyama, T. Kikuchi and T. Asano
  Yakugaku Zasshi 142, 5, 465-471 (2022).

  • URL
  • DOI: 10.1248/yakushi.21-00176-3

  35491150
• "[Recent Advances in the Studies of Metabolic Syndromes and Applications to the Development of New Drugs]"
  A. Kushiyama and Y. Nakatsu
  Yakugaku Zasshi 142, 5, 447-448 (2022).

  • URL
  • DOI: 10.1248/yakushi.21-00176-F

  35491147

2021年

原著論文

• "Quantitative sonographic assessment of quadriceps muscle thickness for fall injury prediction in patients undergoing maintenance hemodialysis: an observational cohort study"
  A. Sai, K. Tanaka, Y. Ohashi, A. Kushiyama, Y. Tanaka, S. Motonishi, K. Sakai, S. Hara and T. Ozawa
  BMC Nephrol 22, 1, 191 (2021).

  • URL
  • DOI: 10.1186/s12882-021-02347-5

  34022848
• "Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis"
  Y. Nakatsu, T. Yamamotoya, M. Okumura, T. Ishii, M. Kanamoto, M. Naito, M. Nakanishi, S. Aoyama, Y. Matsunaga, A. Kushiyama, H. Sakoda, M. Fujishiro, H. Ono and T. Asano
  Metabolism 115, 154459 (2021).

  • URL
  • DOI: 10.1016/j.metabol.2020.154459

  33279499
• "Pathological Role of Pin1 in the Development of DSS-Induced Colitis"
  Y. Matsunaga, S. Hasei, T. Yamamotoya, H. Honda, A. Kushiyama, H. Sakoda, M. Fujishiro, H. Ono, H. Ito, T. Okabe, T. Asano and Y. Nakatsu
  Cells 10, 5 (2021).

  • URL
  • DOI: 10.3390/cells10051230

  34067858
• "Influence of low body weight on long-term clinical outcomes in patients with venous thromboembolism: From the COMMAND VTE registry"
  K. Kaneda, Y. Yamashita, T. Morimoto, H. Amano, T. Takase, S. Hiramori, K. Kim, M. Oi, M. Akao, Y. Kobayashi, M. Toyofuku, Y. Morita, T. Tada, P. M. Chen, K. Murata, Y. Tsuyuki, Y. Nakagawa, Y. Nishimoto, S. Saga, J. Sakamoto, M. Kinoshita, K. Togi, K. Ishii, H. Mabuchi, K. Takabayashi, S. Hojo, T. Kawaji, A. Kushiyama, H. Yaku, K. Nakatsuma, M. Kato, T. Yokomatsu, S. Miki, T. Kimura and C. V. R. Investigators
  Thromb Res 198, 26-33 (2021).

  • URL
  • DOI: 10.1016/j.thromres.2020.11.022

  33264736
• "Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells"
  S. Hasei, T. Yamamotoya, Y. Nakatsu, Y. Ohata, S. Itoga, Y. Nonaka, Y. Matsunaga, H. Sakoda, M. Fujishiro, A. Kushiyama and T. Asano
  Int J Mol Sci 22, 8 (2021).

  • URL
  • DOI: 10.3390/ijms22084040

  33919842
• "Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice"
  J. Hanaguri, H. Yokota, M. Watanabe, S. Yamagami, A. Kushiyama, L. Kuo and T. Nagaoka
  Sci Rep 11, 1, 18401 (2021).

  • URL
  • DOI: 10.1038/s41598-021-97651-3

  34526573
• "Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes"
  M. Fujishiro, H. Ishihara, K. Ogawa, T. Murase, T. Nakamura, K. Watanabe, H. Sakoda, H. Ono, T. Yamamotoya, Y. Nakatsu, T. Asano and A. Kushiyama
  Biomedicines 9, 8 (2021).

  • URL
  • DOI: 10.3390/biomedicines9081052

  34440256
• "Characteristics Associated with Early Worsening of Retinopathy in Patients with Type 2 Diabetes Diagnosed with Retinopathy at Their First Visit: A Retrospective Observational Study"
  S. W. Sugawa, Y. Yoshida, Y. Hikima, H. Sato, A. Shimada, M. Noda and A. Kushiyama
  J Diabetes Res 2021, 7572326 (2021).

  • URL
  • DOI: 10.1155/2021/7572326

  34337073

2020年

原著論文

• "Effect of postprandial hyperglycemia at clinic visits on the incidence of retinopathy in patients with type 2 diabetes: An analysis using real-world long-term follow-up data"
  T. Takao, K. Takahashi, Y. Yoshida, A. Kushiyama, Y. Onishi, T. Tahara, A. Shimmei, T. Kikuchi, M. Suka, H. Yanagisawa, Y. Iwamoto and M. Kasuga
  J Diabetes Investig 11, 4, 930-937 (2020).

  • URL
  • DOI: 10.1111/jdi.13194

  31811705
• "Age-Related Differences in the Effects of Initial Aortic Valve Replacement vs. Conservative Strategy on Long-Term Outcomes in Asymptomatic Patients With Severe Aortic Stenosis"
  A. Kushiyama, T. Taniguchi, T. Morimoto, H. Shiomi, K. Ando, N. Kanamori, K. Murata, T. Kitai, Y. Kawase, C. Izumi, M. Miyake, H. Mitsuoka, M. Kato, Y. Hirano, S. Matsuda, T. Inada, K. Nagao, H. Mabuchi, Y. Takeuchi, K. Yamane, M. Toyofuku, M. Ishii, E. Minamino-Muta, T. Kato, M. Inoko, T. Ikeda, A. Komasa, K. Ishii, K. Hotta, N. Higashitani, Y. Kato, Y. Inuzuka, T. Jinnai, Y. Morikami, N. Saito, K. Minatoya, T. Kimura and C. A. R. Investigators
  Circ J 84, 2, 252-261 (2020).

  • URL
  • DOI: 10.1253/circj.CJ-19-0431

  31875594
• "Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis"
  M. Takahashi, M. Shibasaki, H. Echizen and A. Kushiyama
  PLoS One 15, 7, e0236603 (2020).

  • URL
  • DOI: 10.1371/journal.pone.0236603

  32706828

総説

• "Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells"
  Y. Nakatsu, T. Yamamotoya, K. Ueda, H. Ono, M. K. Inoue, Y. Matsunaga, A. Kushiyama, H. Sakoda, M. Fujishiro, A. Matsubara and T. Asano
  Cancer Lett 470, 106-114 (2020).

  • URL
  • DOI: 10.1016/j.canlet.2019.10.043

  31678165
• "Development of Pin1 Inhibitors and their Potential as Therapeutic Agents"
  Y. Nakatsu, Y. Matsunaga, K. Ueda, T. Yamamotoya, Y. Inoue, M. K. Inoue, Y. Mizuno, A. Kushiyama, H. Ono, M. Fujishiro, H. Ito, T. Okabe and T. Asano
  Curr Med Chem 27, 20, 3314-3329 (2020).

  • URL
  • DOI: 10.2174/0929867325666181105120911

  30394205

2019年

原著論文

• "Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation"
  K. Ueda, Y. Nakatsu, T. Yamamotoya, H. Ono, Y. Inoue, M. K. Inoue, Y. Mizuno, Y. Matsunaga, A. Kushiyama, H. Sakoda, M. Fujishiro, S. I. Takahashi, A. Matsubara and T. Asano
  Oncotarget 10, 17, 1637-1648 (2019).

  • URL
  • DOI: 10.18632/oncotarget.26691

  30899433
• "Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing"
  N. Suzuki, R. Niikura, S. Ihara, Y. Hikiba, H. Kinoshita, N. Higashishima, Y. Hayakawa, A. Yamada, Y. Hirata, R. Nakata, M. Okamoto, M. Sano, A. Kushiyama, M. Ichinose, S. L. Woods, D. Worthley, Y. Iwamoto and K. Koike
  Cancer Prev Res (Phila) 12, 3, 185-194 (2019).

  • URL
  • DOI: 10.1158/1940-6207.CAPR-18-0288

  30700439
• "Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16"
  Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Ueda, M. K. Inoue, Y. Mizuno, M. Nakanishi, T. Sano, Y. Yamawaki, A. Kushiyama, H. Sakoda, M. Fujishiro, A. Ryo, H. Ono, T. Minamino, S. I. Takahashi, H. Ohno, M. Yoneda, K. Takahashi, H. Ishihara, H. Katagiri, F. Nishimura, T. Kanematsu, T. Yamada and T. Asano
  Cell Rep 26, 12, 3221-3230 e3 (2019).

  • URL
  • DOI: 10.1016/j.celrep.2019.02.066

  30893596
• "Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice"
  Y. Mizuno, T. Yamamotoya, Y. Nakatsu, K. Ueda, Y. Matsunaga, M. K. Inoue, H. Sakoda, M. Fujishiro, H. Ono, T. Kikuchi, M. Takahashi, K. Morii, K. Sasaki, T. Masaki, T. Asano and A. Kushiyama
  Int J Mol Sci 20, 19 (2019).

  • URL
  • DOI: 10.3390/ijms20194680

  31546603
• "Association of gait speed and grip strength with risk of cardiovascular events in patients on haemodialysis: a prospective study"
  A. Kuki, K. Tanaka, A. Kushiyama, Y. Tanaka, S. Motonishi, Y. Sugano, T. Furuya and T. Ozawa
  BMC Nephrol 20, 1, 196 (2019).

  • URL
  • DOI: 10.1186/s12882-019-1370-6

  31146702
• "Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP"
  N. Kamatani, A. Kushiyama, L. Toyo-Oka and T. Toyo-Oka
  J Hum Genet 64, 4, 351-353 (2019).

  • URL
  • DOI: 10.1038/s10038-018-0558-0

  30631120
• "Characteristics and Early Hypoglycemic Medications of Patients at Risk of Progression to Type 2 Diabetes in Japan: A Retrospective Cohort Study of Health Checkup and Claims Data"
  N. Kanai, A. Shono, A. Kushiyama and M. Akazawa
  Biol Pharm Bull 42, 12, 2016-2023 (2019).

  • URL
  • DOI: 10.1248/bpb.b19-00505

  31787718
• "Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice"
  M. K. Inoue, Y. Matsunaga, Y. Nakatsu, T. Yamamotoya, K. Ueda, A. Kushiyama, H. Sakoda, M. Fujishiro, H. Ono, M. Iwashita, T. Sano, F. Nishimura, K. Morii, K. Sasaki, T. Masaki and T. Asano
  Diabetol Metab Syndr 11, 57 (2019).

  • URL
  • DOI: 10.1186/s13098-019-0454-6

  31367234

総説

• "Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins"
  M. K. Inoue, Y. Nakatsu, T. Yamamotoya, S. Hasei, M. Kanamoto, M. Naitou, Y. Matsunaga, H. Sakoda, M. Fujishiro, H. Ono, A. Kushiyama and T. Asano
  Cells 8, 12 (2019).

  • URL
  • DOI: 10.3390/cells8121545

  31795496

2018年

原著論文

• "The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model"
  M. K. Inoue, T. Yamamotoya, Y. Nakatsu, K. Ueda, Y. Inoue, Y. Matsunaga, H. Sakoda, M. Fujishiro, H. Ono, K. Morii, K. Sasaki, T. Masaki, Y. Suzuki, T. Asano and A. Kushiyama
  Int J Mol Sci 19, 12 (2018).

  • URL
  • DOI: 10.3390/ijms19123967

  30544662
• "Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages"
  H. Yamazaki, A. Kushiyama, H. Sakoda, M. Fujishiro, T. Yamamotoya, Y. Nakatsu, T. Kikuchi, S. Kaneko, H. Tanaka and T. Asano
  Mediators Inflamm 2018, 3062319 (2018).

  • URL
  • DOI: 10.1155/2018/3062319

  30046278

総説

• "Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications"
  H. Okubo, A. Kushiyama, Y. Nakatsu, T. Yamamotoya, Y. Matsunaga, M. Fujishiro, H. Sakoda, H. Ohno, M. Yoneda and T. Asano
  Int J Mol Sci 19, 10 (2018).

  • URL
  • DOI: 10.3390/ijms19103064

  30297626
• "Gut Microbiota as a Therapeutic Target for Metabolic Disorders"
  H. Okubo, Y. Nakatsu, A. Kushiyama, T. Yamamotoya, Y. Matsunaga, M. K. Inoue, M. Fujishiro, H. Sakoda, H. Ohno, M. Yoneda, H. Ono and T. Asano
  Curr Med Chem 25, 9, 984-1001 (2018).

  • URL
  • DOI: 10.2174/0929867324666171009121702

  28990516

2017年

原著論文

• "Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice"
  T. Yamamotoya, Y. Nakatsu, Y. Matsunaga, T. Fukushima, H. Yamazaki, S. Kaneko, M. Fujishiro, T. Kikuchi, A. Kushiyama, F. Tokunaga, T. Asano and H. Sakoda
  Int J Mol Sci 18, 2 (2017).

  • URL
  • DOI: 10.3390/ijms18020326

  28165393
• "Trk-fused gene (TFG) regulates pancreatic beta cell mass and insulin secretory activity"
  T. Yamamotoya, Y. Nakatsu, A. Kushiyama, Y. Matsunaga, K. Ueda, Y. Inoue, M. K. Inoue, H. Sakoda, M. Fujishiro, H. Ono, H. Kiyonari, H. Ishihara and T. Asano
  Sci Rep 7, 1, 13026 (2017).

  • URL
  • DOI: 10.1038/s41598-017-13432-x

  29026155
• "Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance"
  T. Sano, S. Nagayasu, S. Suzuki, M. Iwashita, A. Yamashita, T. Shinjo, T. Sanui, A. Kushiyama, T. Kanematsu, T. Asano and F. Nishimura
  Nutr Metab Cardiovasc Dis 27, 3, 249-259 (2017).

  • URL
  • DOI: 10.1016/j.numecd.2016.11.008

  28062181
• "Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes"
  Z. Pang, A. Kushiyama, J. Sun, T. Kikuchi, H. Yamazaki, Y. Iwamoto, H. Koriyama, S. Yoshida, M. Shimamura, M. Higuchi, T. Kawano, Y. Takami, H. Rakugi, R. Morishita and H. Nakagami
  FASEB J 31, 9, 4053-4063 (2017).

  • URL
  • DOI: 10.1096/fj.201700110R

  28546444
• "The prolyl isomerase Pin1 increases beta-cell proliferation and enhances insulin secretion"
  Y. Nakatsu, K. Mori, Y. Matsunaga, T. Yamamotoya, K. Ueda, Y. Inoue, K. Mitsuzaki-Miyoshi, H. Sakoda, M. Fujishiro, S. Yamaguchi, A. Kushiyama, H. Ono, H. Ishihara and T. Asano
  J Biol Chem 292, 28, 11886-11895 (2017).

  • URL
  • DOI: 10.1074/jbc.M117.780726

  28566287
• "The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice"
  Y. Nakatsu, H. Kokubo, B. Bumdelger, M. Yoshizumi, T. Yamamotoya, Y. Matsunaga, K. Ueda, Y. Inoue, M. K. Inoue, M. Fujishiro, A. Kushiyama, H. Ono, H. Sakoda and T. Asano
  Int J Mol Sci 18, 8 (2017).

  • URL
  • DOI: 10.3390/ijms18081704

  28777298
• "Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus"
  M. Fujishiro, A. Kushiyama, H. Yamazaki, S. Kaneko, Y. Koketsu, T. Yamamotoya, T. Kikuchi, H. Sakoda, R. Suzuki and T. Kadowaki
  World J Gastroenterol 23, 36, 6694-6704 (2017).

  • URL
  • DOI: 10.3748/wjg.v23.i36.6694

  29085214

2016年

原著論文

• "Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice"
  H. Okubo, A. Kushiyama, H. Sakoda, Y. Nakatsu, M. Iizuka, N. Taki, M. Fujishiro, T. Fukushima, H. Kamata, A. Nagamachi, T. Inaba, F. Nishimura, H. Katagiri, T. Asahara, Y. Yoshida, O. Chonan, J. Encinas and T. Asano
  Sci Rep 6, 20157 (2016).

  • URL
  • DOI: 10.1038/srep20157

  26818807
• "Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1"
  A. Kushiyama, T. Kikuchi, K. Tanaka, T. Tahara, T. Takao, Y. Onishi, Y. Yoshida, S. Kawazu and Y. Iwamoto
  World J Diabetes 7, 11, 230-8 (2016).

  • URL
  • DOI: 10.4239/wjd.v7.i11.230

  27326345
• "C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus"
  R. Sonoda, K. Tanaka, T. Kikuchi, Y. Onishi, T. Takao, T. Tahara, Y. Yoshida, N. Suzawa, S. Kawazu, Y. Iwamoto and A. Kushiyama
  PLoS One 11, 2, e0147303 (2016).

  • URL
  • DOI: 10.1371/journal.pone.0147303

  26849676

総説

• "Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations"
  Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Ueda, Y. Inoue, K. Mori, H. Sakoda, M. Fujishiro, H. Ono, A. Kushiyama and T. Asano
  Int J Mol Sci 17, 9 (2016).

  • URL
  • DOI: 10.3390/ijms17091495

  27618008
• "Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis"
  A. Kushiyama, Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Mori, K. Ueda, Y. Inoue, H. Sakoda, M. Fujishiro, H. Ono and T. Asano
  Mediators Inflamm 2016, 8603164 (2016).

  • URL
  • DOI: 10.1155/2016/8603164

  28070145

2015年

原著論文

• "Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes"
  K. Tanaka, S. Hara, M. Hattori, K. Sakai, Y. Onishi, Y. Yoshida, S. Kawazu and A. Kushiyama
  J Diabetes Investig 6, 1, 98-104 (2015).

  • URL
  • DOI: 10.1111/jdi.12243

  25621139
• "DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappaB activation"
  T. Shinjo, Y. Nakatsu, M. Iwashita, T. Sano, H. Sakoda, H. Ishihara, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Tsuchiya, H. Kamata, F. Nishimura and T. Asano
  Am J Physiol Endocrinol Metab 309, 3, E214-23 (2015).

  • URL
  • DOI: 10.1152/ajpendo.00553.2014

  26015438
• "Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling"
  T. Sano, M. Iwashita, S. Nagayasu, A. Yamashita, T. Shinjo, A. Hashikata, T. Asano, A. Kushiyama, N. Ishimaru, Y. Takahama and F. Nishimura
  Obesity (Silver Spring) 23, 7, 1460-71 (2015).

  • URL
  • DOI: 10.1002/oby.21127

  26097021
• "Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model"
  H. Okubo, Y. Nakatsu, H. Sakoda, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Matsunaga, H. Ohno, M. Yoneda, H. Kamata, T. Shinjo, M. Iwashita, F. Nishimura and T. Asano
  Am J Physiol Gastrointest Liver Physiol 308, 2, G151-8 (2015).

  • URL
  • DOI: 10.1152/ajpgi.00198.2014

  25428903
• "The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model"
  Y. Nakatsu, Y. Seno, A. Kushiyama, H. Sakoda, M. Fujishiro, A. Katasako, K. Mori, Y. Matsunaga, T. Fukushima, R. Kanaoka, T. Yamamotoya, H. Kamata and T. Asano
  Am J Physiol Gastrointest Liver Physiol 309, 1, G42-51 (2015).

  • URL
  • DOI: 10.1152/ajpgi.00443.2014

  25999428
• "Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the gamma subunit"
  Y. Nakatsu, M. Iwashita, H. Sakoda, H. Ono, K. Nagata, Y. Matsunaga, T. Fukushima, M. Fujishiro, A. Kushiyama, H. Kamata, S. Takahashi, H. Katagiri, H. Honda, H. Kiyonari, T. Uchida and T. Asano
  J Biol Chem 290, 40, 24255-66 (2015).

  • URL
  • DOI: 10.1074/jbc.M115.658559

  26276391
• "High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice"
  T. Shinjo, Y. Nakatsu, M. Iwashita, T. Sano, H. Sakoda, H. Ishihara, A. Kushiyama, M. Fujishiro, F. Nishimura and T. Asano
  Diabetol Metab Syndr 7, 50 (2015).

  • URL
  • DOI: 10.1186/s13098-015-0047-y

  26097511
• "Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus"
  S. Qiang, Y. Nakatsu, Y. Seno, M. Fujishiro, H. Sakoda, A. Kushiyama, K. Mori, Y. Matsunaga, T. Yamamotoya, H. Kamata and T. Asano
  Diabetol Metab Syndr 7, 104 (2015).

  • URL
  • DOI: 10.1186/s13098-015-0102-8

  26594248
• "LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis"
  Y. Matsunaga, Y. Nakatsu, T. Fukushima, H. Okubo, M. Iwashita, H. Sakoda, M. Fujishiro, T. Yamamotoya, A. Kushiyama, S. Takahashi, Y. Tsuchiya, H. Kamata, F. Tokunaga, K. Iwai and T. Asano
  Mediators Inflamm 2015, 125380 (2015).

  • URL
  • DOI: 10.1155/2015/125380

  26170532
• "Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines"
  R. Kanaoka, A. Kushiyama, Y. Seno, Y. Nakatsu, Y. Matsunaga, T. Fukushima, Y. Tsuchiya, H. Sakoda, M. Fujishiro, T. Yamamotoya, H. Kamata, A. Matsubara and T. Asano
  PLoS One 10, 6, e0127467 (2015).

  • URL
  • DOI: 10.1371/journal.pone.0127467

  26039047

2014年

原著論文

• "The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease"
  A. Hashikata, A. Yamashita, S. Suzuki, S. Nagayasu, T. Shinjo, A. Taniguchi, M. Fukushima, Y. Nakai, K. Nin, N. Watanabe, T. Asano, Y. Abiko, A. Kushiyama, S. Nagasaka and F. Nishimura
  Nephrol Dial Transplant 29, 3, 611-8 (2014).

  • URL
  • DOI: 10.1093/ndt/gft449

  24235082

総説

• "Linking uric acid metabolism to diabetic complications"
  A. Kushiyama, K. Tanaka, S. Hara and S. Kawazu
  World J Diabetes 5, 6, 787-95 (2014).

  • URL
  • DOI: 10.4239/wjd.v5.i6.787

  25512781

2013年

原著論文

• "Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions"
  J. Zhang, Y. Nakatsu, T. Shinjo, Y. Guo, H. Sakoda, T. Yamamotoya, Y. Otani, H. Okubo, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Tsuchiya, H. Kamata, M. Iwashita, F. Nishimura, H. Katagiri, S. Takahashi, H. Kurihara, T. Uchida and T. Asano
  J Biol Chem 288, 28, 20692-701 (2013).

  • URL
  • DOI: 10.1074/jbc.M113.485730

  23720771
• "Integrator complex plays an essential role in adipose differentiation"
  Y. Otani, Y. Nakatsu, H. Sakoda, T. Fukushima, M. Fujishiro, A. Kushiyama, H. Okubo, Y. Tsuchiya, H. Ohno, S. Takahashi, F. Nishimura, H. Kamata, H. Katagiri and T. Asano
  Biochem Biophys Res Commun 434, 2, 197-202 (2013).

  • URL
  • DOI: 10.1016/j.bbrc.2013.03.029

  23523797
• "Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model"
  H. Okubo, H. Sakoda, A. Kushiyama, M. Fujishiro, Y. Nakatsu, T. Fukushima, Y. Matsunaga, H. Kamata, T. Asahara, Y. Yoshida, O. Chonan, M. Iwashita, F. Nishimura and T. Asano
  Am J Physiol Gastrointest Liver Physiol 305, 12, G911-8 (2013).

  • URL
  • DOI: 10.1152/ajpgi.00225.2013

  24113768
• "Twenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan"
  A. Kushiyama, Y. Yoshida, T. Kikuchi, N. Suzawa, M. Yamamoto, K. Tanaka, M. Okayasu, T. Tahara, T. Takao, Y. Onishi and S. Kawazu
  J Diabetes Investig 4, 6, 540-5 (2013).

  • URL
  • DOI: 10.1111/jdi.12090

  24843707
• "Resistin-like molecule beta is abundantly expressed in foam cells and is involved in atherosclerosis development"
  A. Kushiyama, H. Sakoda, N. Oue, M. Okubo, Y. Nakatsu, H. Ono, T. Fukushima, H. Kamata, F. Nishimura, T. Kikuchi, M. Fujishiro, K. Nishiyama, H. Aburatani, S. Kushiyama, M. Iizuka, N. Taki, J. Encinas, K. Sentani, N. Ogonuki, A. Ogura, S. Kawazu, W. Yasui, Y. Higashi, H. Kurihara, H. Katagiri and T. Asano
  Arterioscler Thromb Vasc Biol 33, 8, 1986-93 (2013).

  • URL
  • DOI: 10.1161/ATVBAHA.113.301546

  23702657
• "Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice"
  M. Iwashita, Y. Nakatsu, H. Sakoda, M. Fujishiro, A. Kushiyama, T. Fukushima, S. Kumamoto, T. Shinjo, H. Kamata, F. Nishimura and T. Asano
  Adipocyte 2, 1, 28-32 (2013).

  • URL
  • DOI: 10.4161/adip.21837

  23700549

2012年

原著論文

• "Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model"
  Y. Nakatsu, Y. Otani, H. Sakoda, J. Zhang, Y. Guo, H. Okubo, A. Kushiyama, M. Fujishiro, T. Kikuch, T. Fukushima, H. Ohno, Y. Tsuchiya, H. Kamata, A. Nagamachi, T. Inaba, F. Nishimura, H. Katagiri, S. Takahashi, H. Kurihara, T. Uchida and T. Asano
  J Biol Chem 287, 53, 44526-35 (2012).

  • URL
  • DOI: 10.1074/jbc.M112.397133

  23112047
• "Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications"
  H. Nakarai, A. Yamashita, S. Nagayasu, M. Iwashita, S. Kumamoto, H. Ohyama, M. Hata, Y. Soga, A. Kushiyama, T. Asano, Y. Abiko and F. Nishimura
  Innate Immun 18, 1, 164-70 (2012).

  • URL
  • DOI: 10.1177/1753425910393370

  21239459
• "Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development"
  A. Kushiyama, H. Okubo, H. Sakoda, T. Kikuchi, M. Fujishiro, H. Sato, S. Kushiyama, M. Iwashita, F. Nishimura, T. Fukushima, Y. Nakatsu, H. Kamata, S. Kawazu, Y. Higashi, H. Kurihara and T. Asano
  Arterioscler Thromb Vasc Biol 32, 2, 291-8 (2012).

  • URL
  • DOI: 10.1161/ATVBAHA.111.234559

  22095983
• "Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages"
  S. Kumamoto, A. Kushiyama, Y. Nakatsu, H. Sakoda, M. Fujishiro, M. Iwashita, H. Ohno, J. Zhang, Y. Guo, H. Aburatani, H. Kamata, F. Nishimura and T. Asano
  Obes Res Clin Pract 6, 4, e263-346 (2012).

  • URL
  • DOI: 10.1016/j.orcp.2012.05.005

  24331589
• "LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8"
  T. Kikuchi, J. Zhang, H. Sakoda, Y. Koketsu, M. Fujishiro, A. Kushiyama, Y. Nakatsu, H. Kamata, K. Inoki, S. Takahashi, H. Kurihara, K. Hideki, Y. Oka and T. Asano
  Obes Res Clin Pract 6, 3, e175-262 (2012).

  • URL
  • DOI: 10.1016/j.orcp.2011.10.002

  24331524
• "Valsartan, independently of AT1 receptor or PPARgamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes"
  M. Iwashita, H. Sakoda, A. Kushiyama, M. Fujishiro, H. Ohno, Y. Nakatsu, T. Fukushima, S. Kumamoto, Y. Tsuchiya, T. Kikuchi, H. Kurihara, H. Akazawa, I. Komuro, H. Kamata, F. Nishimura and T. Asano
  Am J Physiol Endocrinol Metab 302, 3, E286-96 (2012).

  • URL
  • DOI: 10.1152/ajpendo.00324.2011

  22045314

2011年

原著論文

• "Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia"
  K. Tanaka, S. Hara, A. Kushiyama, Y. Ubara, Y. Yoshida, S. Mizuiri, A. Aikawa and S. Kawatzu
  Clin Exp Nephrol 15, 3, 391-397 (2011).

  • URL
  • DOI: 10.1007/s10157-011-0420-6

  21331740
• "4F2hc stabilizes GLUT1 protein and increases glucose transport activity"
  H. Ohno, Y. Nakatsu, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, Y. Otani, H. Okubo, M. Yoneda, T. Fukushima, Y. Tsuchiya, H. Kamata, F. Nishimura, H. Kurihara, H. Katagiri, Y. Oka and T. Asano
  Am J Physiol Cell Physiol 300, 5, C1047-54 (2011).

  • URL
  • DOI: 10.1152/ajpcell.00416.2010

  21270293
• "Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis"
  Y. Nakatsu, H. Sakoda, A. Kushiyama, J. Zhang, H. Ono, M. Fujishiro, T. Kikuchi, T. Fukushima, M. Yoneda, H. Ohno, N. Horike, M. Kanna, Y. Tsuchiya, H. Kamata, F. Nishimura, T. Isobe, T. Ogihara, H. Katagiri, Y. Oka, S. Takahashi, H. Kurihara, T. Uchida and T. Asano
  J Biol Chem 286, 23, 20812-22 (2011).

  • URL
  • DOI: 10.1074/jbc.M110.206904

  21454638
• "Atrio-His (James) accessory pathway and infiltration of gammadelta T cells in the heart with MELAS"
  G. Matsuzaki, A. Kushiyama, K. Uto, M. Shoda and Y. Seko
  BMJ Case Rep 2011 (2011).

  • URL
  • DOI: 10.1136/bcr.09.2010.3359

  22714618

2010年

原著論文

• "Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase"
  M. Yoneda, Y. Guo, H. Ono, Y. Nakatsu, J. Zhang, X. Cui, M. Iwashita, S. Kumamoto, Y. Tsuchiya, H. Sakoda, M. Fujishiro, A. Kushiyama, Y. Koketsu, T. Kikuchi, H. Kamata, F. Nishimura and T. Asano
  Obes Res Clin Pract 4, 3, e163-246 (2010).

  • URL
  • DOI: 10.1016/j.orcp.2010.02.002

  24345663
• "Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity"
  Y. Nakatsu, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, N. Horike, M. Yoneda, H. Ohno, Y. Tsuchiya, H. Kamata, H. Tahara, T. Isobe, F. Nishimura, H. Katagiri, Y. Oka, T. Fukushima, S. I. Takahashi, H. Kurihara, T. Uchida and T. Asano
  J Biol Chem 285, 43, 33018-33027 (2010).

  • URL
  • DOI: 10.1074/jbc.M110.137836

  20675384
• "Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy"
  X. Cui, A. Kushiyama, M. Yoneda, Y. Nakatsu, Y. Guo, J. Zhang, H. Ono, M. Kanna, H. Sakoda, H. Ono, T. Kikuchi, M. Fujishiro, M. Shiomi, H. Kamata, H. Kurihara, M. Kikuchi, S. Kawazu, F. Nishimura and T. Asano
  Diabetes Res Clin Pract 87, 1, 57-63 (2010).

  • URL
  • DOI: 10.1016/j.diabres.2009.10.011

  19939487

2008年

原著論文

• "Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice"
  Y. Koketsu, H. Sakoda, M. Fujishiro, A. Kushiyama, Y. Fukushima, H. Ono, M. Anai, T. Kikuchi, T. Fukuda, H. Kamata, N. Horike, Y. Uchijima, H. Kurihara and T. Asano
  Am J Physiol Endocrinol Metab 294, 4, E719-25 (2008).

  • URL
  • DOI: 10.1152/ajpendo.00253.2007

  18270303
• "AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver"
  N. Horike, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, H. Kamata, K. Nishiyama, Y. Uchijima, Y. Kurihara, H. Kurihara and T. Asano
  J Biol Chem 283, 49, 33902-10 (2008).

  • URL
  • DOI: 10.1074/jbc.M802537200

  18801732
• "Regulation of gut-derived resistin-like molecule beta expression by nutrients"
  J. Fujio, A. Kushiyama, H. Sakoda, M. Fujishiro, T. Ogihara, Y. Fukushima, M. Anai, N. Horike, H. Kamata, Y. Uchijima, H. Kurihara and T. Asano
  Diabetes Res Clin Pract 79, 1, 2-10 (2008).

  • URL
  • DOI: 10.1016/j.diabres.2007.04.015

  17936398
• "Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells"
  M. Egawa, H. Kamata, A. Kushiyama, H. Sakoda, M. Fujishiro, N. Horike, M. Yoneda, Y. Nakatsu, G. Ying, Z. Jun, Y. Tsuchiya, K. Takata, H. Kurihara and T. Asano
  Placenta 29, 12, 1003-8 (2008).

  • URL
  • DOI: 10.1016/j.placenta.2008.09.008

  18950855

2007年

原著論文

• "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways"
  H. Ono, H. Sakoda, M. Fujishiro, M. Anai, A. Kushiyama, Y. Fukushima, H. Katagiri, T. Ogihara, Y. Oka, H. Kamata, N. Horike, Y. Uchijima, H. Kurihara and T. Asano
  Am J Physiol Cell Physiol 293, 5, C1576-85 (2007).

  • URL
  • DOI: 10.1152/ajpcell.00570.2006

  17615157

総説

• "Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions"
  T. Asano, M. Fujishiro, A. Kushiyama, Y. Nakatsu, M. Yoneda, H. Kamata and H. Sakoda
  Biol Pharm Bull 30, 9, 1610-6 (2007).

  • URL
  • DOI: 10.1248/bpb.30.1610

  17827708

2006年

原著論文

• "Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression"
  A. Y. Viana, H. Sakoda, M. Anai, M. Fujishiro, H. Ono, A. Kushiyama, Y. Fukushima, Y. Sato, Y. Oshida, Y. Uchijima, H. Kurihara and T. Asano
  Diabetes Res Clin Pract 73, 2, 135-42 (2006).

  • URL
  • DOI: 10.1016/j.diabres.2005.12.011

  16503364

総説

• "Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance"
  T. Asano, H. Sakosda, M. Fujishiro, M. Anai, A. Kushiyama, N. Horike, H. Kamata, T. Ogihara, H. Kurihara and Y. Uchijima
  Curr Diabetes Rev 2, 4, 449-54 (2006).

  • URL
  • DOI: 10.2174/1573399810602040449

  18220647

2005年

原著論文

• "Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet"
  A. Kushiyama, N. Shojima, T. Ogihara, K. Inukai, H. Sakoda, M. Fujishiro, Y. Fukushima, M. Anai, H. Ono, N. Horike, A. Y. Viana, Y. Uchijima, K. Nishiyama, T. Shimosawa, T. Fujita, H. Katagiri, Y. Oka, H. Kurihara and T. Asano
  J Biol Chem 280, 51, 42016-25 (2005).

  • URL
  • DOI: 10.1074/jbc.M503065200

  16243841
• "Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow"
  N. Shojima, T. Ogihara, K. Inukai, M. Fujishiro, H. Sakoda, A. Kushiyama, H. Katagiri, M. Anai, H. Ono, Y. Fukushima, N. Horike, A. Y. Viana, Y. Uchijima, H. Kurihara and T. Asano
  Diabetologia 48, 5, 984-92 (2005).

  • URL
  • DOI: 10.1007/s00125-005-1735-1

  15834545
• "Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity"
  H. Sakoda, M. Fujishiro, J. Fujio, N. Shojima, T. Ogihara, A. Kushiyama, Y. Fukushima, M. Anai, H. Ono, M. Kikuchi, N. Horike, A. Y. Viana, Y. Uchijima, H. Kurihara and T. Asano
  Am J Physiol Endocrinol Metab 289, 3, E474-81 (2005).

  • URL
  • DOI: 10.1152/ajpendo.00003.2005

  15886229

2004年

原著論文

• "Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase"
  T. Ogihara, T. Asano, H. Katagiri, H. Sakoda, M. Anai, N. Shojima, H. Ono, M. Fujishiro, A. Kushiyama, Y. Fukushima, M. Kikuchi, N. Noguchi, H. Aburatani, Y. Gotoh, I. Komuro and T. Fujita
  Diabetologia 47, 5, 794-805 (2004).

  • URL
  • DOI: 10.1007/s00125-004-1391-x

  15127200
• "Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa"
  Y. Fukushima, T. Matsui, T. Saitoh, M. Ichinose, K. Tateishi, T. Shindo, M. Fujishiro, H. Sakoda, N. Shojima, A. Kushiyama, S. Fukuda, M. Anai, H. Ono, M. Oka, Y. Shimizu, H. Kurihara, R. Nagai, T. Ishikawa, T. Asano and M. Omata
  Eur J Pharmacol 502, 3, 243-52 (2004).

  • URL
  • DOI: 10.1016/j.ejphar.2004.09.013

  15476751

2003年

原著論文

• "Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells"
  Y. Fukushima, T. Ishikawa, T. Saitoh, K. Tateishi, T. Ogihara, M. Fujishiro, N. Shojima, M. Honda, A. Kushiyama, M. Anai, H. Sakoda, H. Ono, Y. Onishi, H. Otsuka, H. Katagiri, R. Nagai, M. Omata and T. Asano
  Digestion 68, 45691, 145-52 (2003).

  • URL
  • DOI: 10.1159/000075349

  14671421