研究業績

総説

2022年

• "[Metabolism-dependent Vascular Pathophysiology in Adult Diseases]"
  A. Kushiyama, M. Takahashi, S. Kushiyama, T. Kikuchi and T. Asano
  Yakugaku Zasshi 142, 5, 465-471 (2022).

  • URL
  • DOI: 10.1248/yakushi.21-00176-3

  35491150
• "[Recent Advances in the Studies of Metabolic Syndromes and Applications to the Development of New Drugs]"
  A. Kushiyama and Y. Nakatsu
  Yakugaku Zasshi 142, 5, 447-448 (2022).

  • URL
  • DOI: 10.1248/yakushi.21-00176-F

  35491147

2020年

• "Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells"
  Y. Nakatsu, T. Yamamotoya, K. Ueda, H. Ono, M. K. Inoue, Y. Matsunaga, A. Kushiyama, H. Sakoda, M. Fujishiro, A. Matsubara and T. Asano
  Cancer Lett 470, 106-114 (2020).

  • URL
  • DOI: 10.1016/j.canlet.2019.10.043

  31678165
• "Development of Pin1 Inhibitors and their Potential as Therapeutic Agents"
  Y. Nakatsu, Y. Matsunaga, K. Ueda, T. Yamamotoya, Y. Inoue, M. K. Inoue, Y. Mizuno, A. Kushiyama, H. Ono, M. Fujishiro, H. Ito, T. Okabe and T. Asano
  Curr Med Chem 27, 20, 3314-3329 (2020).

  • URL
  • DOI: 10.2174/0929867325666181105120911

  30394205

2019年

• "Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins"
  M. K. Inoue, Y. Nakatsu, T. Yamamotoya, S. Hasei, M. Kanamoto, M. Naitou, Y. Matsunaga, H. Sakoda, M. Fujishiro, H. Ono, A. Kushiyama and T. Asano
  Cells 8, 12 (2019).

  • URL
  • DOI: 10.3390/cells8121545

  31795496

2018年

• "Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications"
  H. Okubo, A. Kushiyama, Y. Nakatsu, T. Yamamotoya, Y. Matsunaga, M. Fujishiro, H. Sakoda, H. Ohno, M. Yoneda and T. Asano
  Int J Mol Sci 19, 10 (2018).

  • URL
  • DOI: 10.3390/ijms19103064

  30297626
• "Gut Microbiota as a Therapeutic Target for Metabolic Disorders"
  H. Okubo, Y. Nakatsu, A. Kushiyama, T. Yamamotoya, Y. Matsunaga, M. K. Inoue, M. Fujishiro, H. Sakoda, H. Ohno, M. Yoneda, H. Ono and T. Asano
  Curr Med Chem 25, 9, 984-1001 (2018).

  • URL
  • DOI: 10.2174/0929867324666171009121702

  28990516

2016年

• "Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations"
  Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Ueda, Y. Inoue, K. Mori, H. Sakoda, M. Fujishiro, H. Ono, A. Kushiyama and T. Asano
  Int J Mol Sci 17, 9 (2016).

  • URL
  • DOI: 10.3390/ijms17091495

  27618008
• "Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis"
  A. Kushiyama, Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Mori, K. Ueda, Y. Inoue, H. Sakoda, M. Fujishiro, H. Ono and T. Asano
  Mediators Inflamm 2016, 8603164 (2016).

  • URL
  • DOI: 10.1155/2016/8603164

  28070145

2014年

• "Linking uric acid metabolism to diabetic complications"
  A. Kushiyama, K. Tanaka, S. Hara and S. Kawazu
  World J Diabetes 5, 6, 787-95 (2014).

  • URL
  • DOI: 10.4239/wjd.v5.i6.787

  25512781

2007年

• "Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions"
  T. Asano, M. Fujishiro, A. Kushiyama, Y. Nakatsu, M. Yoneda, H. Kamata and H. Sakoda
  Biol Pharm Bull 30, 9, 1610-6 (2007).

  • URL
  • DOI: 10.1248/bpb.30.1610

  17827708

2006年

• "Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance"
  T. Asano, H. Sakosda, M. Fujishiro, M. Anai, A. Kushiyama, N. Horike, H. Kamata, T. Ogihara, H. Kurihara and Y. Uchijima
  Curr Diabetes Rev 2, 4, 449-54 (2006).

  • URL
  • DOI: 10.2174/1573399810602040449

  18220647