研究業績

2019年

原著論文

• "Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation"
  K. Ueda, Y. Nakatsu, T. Yamamotoya, H. Ono, Y. Inoue, M. K. Inoue, Y. Mizuno, Y. Matsunaga, A. Kushiyama, H. Sakoda, M. Fujishiro, S. I. Takahashi, A. Matsubara and T. Asano
  Oncotarget 10, 17, 1637-1648 (2019).

  • URL
  • DOI: 10.18632/oncotarget.26691

  30899433
• "Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing"
  N. Suzuki, R. Niikura, S. Ihara, Y. Hikiba, H. Kinoshita, N. Higashishima, Y. Hayakawa, A. Yamada, Y. Hirata, R. Nakata, M. Okamoto, M. Sano, A. Kushiyama, M. Ichinose, S. L. Woods, D. Worthley, Y. Iwamoto and K. Koike
  Cancer Prev Res (Phila) 12, 3, 185-194 (2019).

  • URL
  • DOI: 10.1158/1940-6207.CAPR-18-0288

  30700439
• "Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16"
  Y. Nakatsu, Y. Matsunaga, T. Yamamotoya, K. Ueda, M. K. Inoue, Y. Mizuno, M. Nakanishi, T. Sano, Y. Yamawaki, A. Kushiyama, H. Sakoda, M. Fujishiro, A. Ryo, H. Ono, T. Minamino, S. I. Takahashi, H. Ohno, M. Yoneda, K. Takahashi, H. Ishihara, H. Katagiri, F. Nishimura, T. Kanematsu, T. Yamada and T. Asano
  Cell Rep 26, 12, 3221-3230 e3 (2019).

  • URL
  • DOI: 10.1016/j.celrep.2019.02.066

  30893596
• "Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice"
  Y. Mizuno, T. Yamamotoya, Y. Nakatsu, K. Ueda, Y. Matsunaga, M. K. Inoue, H. Sakoda, M. Fujishiro, H. Ono, T. Kikuchi, M. Takahashi, K. Morii, K. Sasaki, T. Masaki, T. Asano and A. Kushiyama
  Int J Mol Sci 20, 19 (2019).

  • URL
  • DOI: 10.3390/ijms20194680

  31546603
• "Association of gait speed and grip strength with risk of cardiovascular events in patients on haemodialysis: a prospective study"
  A. Kuki, K. Tanaka, A. Kushiyama, Y. Tanaka, S. Motonishi, Y. Sugano, T. Furuya and T. Ozawa
  BMC Nephrol 20, 1, 196 (2019).

  • URL
  • DOI: 10.1186/s12882-019-1370-6

  31146702
• "Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP"
  N. Kamatani, A. Kushiyama, L. Toyo-Oka and T. Toyo-Oka
  J Hum Genet 64, 4, 351-353 (2019).

  • URL
  • DOI: 10.1038/s10038-018-0558-0

  30631120
• "Characteristics and Early Hypoglycemic Medications of Patients at Risk of Progression to Type 2 Diabetes in Japan: A Retrospective Cohort Study of Health Checkup and Claims Data"
  N. Kanai, A. Shono, A. Kushiyama and M. Akazawa
  Biol Pharm Bull 42, 12, 2016-2023 (2019).

  • URL
  • DOI: 10.1248/bpb.b19-00505

  31787718
• "Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice"
  M. K. Inoue, Y. Matsunaga, Y. Nakatsu, T. Yamamotoya, K. Ueda, A. Kushiyama, H. Sakoda, M. Fujishiro, H. Ono, M. Iwashita, T. Sano, F. Nishimura, K. Morii, K. Sasaki, T. Masaki and T. Asano
  Diabetol Metab Syndr 11, 57 (2019).

  • URL
  • DOI: 10.1186/s13098-019-0454-6

  31367234

総説

• "Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins"
  M. K. Inoue, Y. Nakatsu, T. Yamamotoya, S. Hasei, M. Kanamoto, M. Naitou, Y. Matsunaga, H. Sakoda, M. Fujishiro, H. Ono, A. Kushiyama and T. Asano
  Cells 8, 12 (2019).

  • URL
  • DOI: 10.3390/cells8121545

  31795496